Udana made his first-class and List A whilst playing for the Sri Lanka A team during their tour to South Africa in August and September 2008. He subsequently went on to play for Tamil Union in both forms during the 2008–09 season. He was then selected by Wayamba to play in both the first-class and Twenty20 portions of the Sri Lankan Inter-Provincial Cricket Tournament.
Isuru Udana took a hat-trick in Champions League Twenty20, 2010 with the wickets of Patton, Sinclair and Worker. He took hattrick only two balls -- first wicket caught behind, 2nd wicket stump at wide delivery and on next delivery Worker bowled.